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假牙黏著剂怎么选？可以黏多久？｜證據鏈

km 編輯部2026-08-13阅读约 70 分钟
#證據鏈#牙醫KM#假牙#口腔健康

本頁是〈假牙黏著剂怎么选？可以黏多久？〉的事實單元帳：每一條主張對應的來源、證據等級、地域與期間、原文引句與限制，逐條攤開。

假牙黏著剂怎么选？可以黏多久？｜證據鏈

F-Units（事实单元帐）

  • F1｜confidence: verified｜basis: peer_reviewed（PMID 33888328，范畴回顾 scoping review）｜period: 检索 2020-10，2022 刊出｜geo: universal｜span: 「Commercially available denture adhesives have a dose-dependent cytotoxic effect on fibroblasts and keratinocytes, with poor cell recovery noted in older human fibroblasts. Patients presented different levels of neurologic or hematological alterations associated with the excessive use of denture adhesives.」「Most commercially available denture adhesives have a dose-dependent cytotoxic effect, and the use of well-adapted removable dental prostheses, proper patient follow-ups, and correct instructions for their use when indicated should be a priority.」｜caveat: 范畴回顾不作疗效或安全性的统合估计，仅描绘文献地图；纳入 33 篇（14 篇体外、19 篇临床）
  • F2｜confidence: verified｜basis: peer_reviewed（PMID 27918740，系统性回顾）｜period: 检索 2005-01 至 2015-10，2017 刊出｜geo: universal｜span: 「Out of the 190 studies obtained initially from the search 16 articles were selected to be included in our systematic review. The prevalence of denture stomatitis was 29.56% and 4.44% for IPH.」「Smoking and continued use of ill-fitting dentures turned out to be the most frequent risk factors for developing IPH.」｜caveat: 盛行率为纳入研究的合并描述、非人口普查；本卡引用其风险因子叙述，不作因果推论；该回顾未评估黏著剂
  • F3｜confidence: verified｜basis: peer_reviewed（PMID 33727079，系统性回顾与统合分析）｜period: 检索至 2020-03，2021 刊出；非现行检索日期最新者，较新者见 F4（检索至 2023-07）｜geo: universal｜span: 「Of the 1729 records identified, 39 studies (43 articles) were included in the analysis. Among them, 23 were RCTs and 16 were CCTs, with two multicenter clinical trials (1 RCT and 1 CCT). Meta-analysis results indicated that DAs provided significantly higher retention (SMD 1.34, 95 % CI: 0.89-1.79, P < 0.001) for CDs. Bite force (SMD 0.98, 95 % CI: 0.50-1.47, P < 0.001) and masticatory performance (SMD 0.72, 95 % CI: 0.23-1.22, P = 0.004) of the CD wearers were also improved after using DAs, but the effect size was relatively smaller.」｜caveat: 纳入含非随机对照试验；效果量为标准化平均差，不可换算成个人可感受的改善幅度
  • F4｜confidence: verified｜basis: peer_reviewed（PMID 38183500，系统性回顾与网络统合分析，PROSPERO CRD42023451045）｜period: 检索自资料库建立至 2023-07，2024 刊出＝本卡纳入之黏著剂效果回顾中检索日期较新者（2026-08-06 以 PubMed 对 "denture adhesive"[tiab] 并 systematic[sb] 重查 12 笔，未见检索日期更新者）｜geo: universal｜span: 「Seventeen articles were included in the quantitative analysis. Cream denture adhesives significantly increased bite force in both incisal region (RR = 7.63[95%CI: 3.34, 11.91]) (P < .05) as well as premolar and molar regions (RR = 33.66[95%CI: 15.15, 52.16]).」「Powder adhesives significantly increased premolar and molar bite force (RR = 36.00[95%CI: 16.20, 55.79]) (P < .05) and Kapur's index of retention (mandibular denture) (RR = 1.54[95%CI: 0.58, 2.49]) (P = 0.002).」「Cream and powder denture adhesives are effective in enhancing the retention of mandibular dentures (Kapur's index) and bite force in the premolar/molar region in complete denture wearers (moderate level of certainty of evidence).」｜caveat: 网络统合分析含间接比较，排名（SUCRA）本卡不引用；效果指标为研究情境下的量测值，非个人预期值
  • F5｜confidence: verified｜basis: peer_reviewed（PMID 34772484，系统性回顾与统合分析）｜period: 检索至 2021-07，2023 刊出｜geo: universal｜span: 「Nine studies (6 randomized and 3 nonrandomized clinical trials) were included. The risk of bias was considered moderate. Meta-analyses showed no differences between cream and powder denture adhesives for masticatory performance (standard mean difference=0.02; 95% CI=-0.46 to 0.50, P=.93) or between cream and strip denture adhesives for occlusal force (mean difference=14.35; 95% CI=-11.14 to 39.84, P=.27).」「However, for resorbed ridges, cream denture adhesive resulted in a higher masticatory performance than strip (P<.05). When comparing powder to strip denture adhesives, the occlusal force was higher in the powder group (P<.05). The certainty of evidence was very low for all evaluated outcomes.」｜caveat: 次人群结果（牙槽嵴吸收者）来自质性分析、非统合估计，证据确定性极低，不可作为选型准则
  • F6｜confidence: verified｜basis: peer_reviewed（PMID 33438306，系统性回顾）｜period: 检索自资料库建立至 2020-02-06，2021 刊出｜geo: universal｜span: 「A total of 497 abstracts were reviewed, resulting in inclusion of 10 RCTs.」「All 10 studies were assessed at unclear (10%) or high risk of bias (90%).」「Due to the heterogeneity of the outcomes, unclear/high risk of bias and small sample sizes, the quality of the evidence was very low.」｜caveat: 仅收双颚全口假牙的随机对照试验，不涵盖局部可摘义齿
  • F7｜confidence: verified｜basis: peer_reviewed（PMID 33551134，系统性回顾）｜period: 检索至 2020-10，2022 刊出｜geo: universal｜span: 「Thirteen studies were included with a total of 516 participants with a mean age of 65.5 years.」「Most studies presented a low risk of bias, but the certainty of the evidence was classified as low to moderate.」｜caveat: 与 F6 对偏误风险的评估结论不一致（一份评为多数低偏误、一份评为 90% 高偏误），本卡并列不择一
  • F8｜confidence: verified｜basis: peer_reviewed（PMID 37805705，随机对照交叉试验）｜period: 2024 刊出｜geo: universal｜span: 「Twenty-two participants with a fair-to-poor fitting maxillary denture opposed by natural dentition or a stable mandibular denture were enrolled in this single-center, randomized, double-blind, two-treatment, 4-period crossover study.」「bite force measurements were retaken at 1, 3, 5, 7, 9, 11, and 13 h.」「There were 15 females and 7 males with a mean age of 70 years.」「Both adhesives showed a statistically significant increase in bite force (p < 0.001) at each time point compared to no adhesive.」｜caveat: 单中心、22 人、厂商配方比较试验；本卡不引用其两款产品之优劣比较结论，仅引用「相对于未使用黏著剂」的时间点结果；13 小时为量测期上限，非使用时数建议
  • F9｜confidence: verified｜basis: peer_reviewed（PMID 30942961，随机对照交叉试验）｜period: 2018 刊出｜geo: universal｜span: 「aimed to compare three experimental adhesives ("Adhesive 1," "Adhesive 2," "Adhesive 3") with slightly different formulations and a commercially marketed "Positive control" with a "No Adhesive" arm using incisal bite force measurements over 12 hours in subjects with a moderately well- to well-fitting maxillary denture.」「This procedure was repeated at 0.5, 1, 3, 6, 9, and 12 hours after adhesive application」「A total of 48 subjects completed the study. All experimental formulations showed statistically significantly higher bite force measurements compared to the No Adhesive arm at all time points」｜caveat: 受试者为贴合度中等偏佳至良好之上颚假牙者；本卡不引用其产品间比较结论；12 小时为量测期上限
  • F10｜confidence: verified｜basis: peer_reviewed（PMID 25294364，前瞻世代研究）｜period: 3 年追踪，2015 刊出｜geo: universal（日本社区长者世代，非制度陈述）｜span: 「At baseline, 524 randomly selected seniors (228 men and 296 women; mean age, 87.8 years) were examined for oral health status and oral hygiene behaviors」「During a 3-year follow-up period, 48 events associated with pneumonia (20 deaths and 28 acute hospitalizations) were identified. Among 453 denture wearers, 186 (40.8%) who wore their dentures during sleep were at higher risk for pneumonia than those who removed their dentures at night (log rank P = 0.021).」「for denture wearing during sleep, HR, 2.38; and 95% CI, 1.25-4.56」「those who wore dentures during sleep were more likely to have tongue and denture plaque, gum inflammation, positive culture for Candida albicans, and higher levels of circulating interleukin-6 as compared with their counterparts.」｜caveat: 观察性研究，仅能显示相关而非因果；人群为平均 87.8 岁之社区极高龄者，不可外推至一般成人；该研究未直接评估黏著剂
  • F11｜confidence: verified｜basis: peer_reviewed（PMID 18525032，个案系列）｜period: 2008 刊出｜geo: universal｜span: 「We identified four patients, one previously reported, with various neurologic abnormalities in the setting of hypocupremia and hyperzincemia. Each of these patients wore dentures and used very large amounts of denture cream chronically.」「Zinc concentrations ranging from about 17,000 to 34,000 mug/g were identified in…denture creams.」「Denture cream contains zinc, and chronic excessive use may result in hypocupremia and serious neurologic disease.」｜caveat: 个案系列（n=4），证据等级低于对照研究；span 以 … 省略原文中的商品名，本卡不列任何品牌；所测样本为 2008 年当时之产品，不代表现售产品之含锌量
  • F12｜confidence: verified｜basis: peer_reviewed（PMID 42087025，系统性回顾）｜period: 收录 1972 至 2025 年个案，2026 刊出＝本卡锌毒性面向检索日期最新者｜geo: universal｜span: 「Thirty-four publications describing 37 individual cases were included, spanning from 1972 to 2025. Zinc exposure most commonly resulted from oral supplements, denture adhesive creams, and coin ingestion, with reported daily elemental zinc doses ranging from approximately 50 mg to more than 1500 mg and exposure durations ranging from weeks to years.」「Serum copper levels were reduced in all patients.」「Discontinuation of zinc exposure with copper supplementation resulted in hematologic recovery in the majority of cases, typically within weeks to months, while neurological manifestations improved more slowly and were sometimes incomplete.」｜caveat: 纳入者为描述性研究与个案报告，属罕见事件之汇整，不能用来估计使用者的发生率；每日锌剂量范围涵盖所有暴露来源，非单指黏著剂
  • F13｜confidence: verified｜basis: peer_reviewed（PMID 20493327，文献回顾）｜period: 2010 刊出｜geo: universal｜span: 「This condition causes elevation of serum zinc levels that result in depression of serum copper. The low serum copper levels cause bone marrow depression and widespread sensory and motor neuropathies.」「Denture patients must be advised of the risks of prolonged overuse of denture adhesives.」｜caveat: 叙述性回顾、非系统性回顾；刊出于 2010 年，较新的汇整见 F12
  • F14｜confidence: verified｜basis: peer_reviewed（PMID 40063077，体外比较研究）｜period: 2025 刊出｜geo: universal｜span: 「The current trend in denture adhesives is shifting toward zinc-free formulations due to the significant health concerns associated with zinc.」｜caveat: 本卡仅引用其背景段落对配方趋势的陈述，未引用其流变学结果；此为研究者陈述，非市场普查或主管机关统计；个别产品是否含锌仍以该产品成分标示为准
  • F15｜confidence: verified｜basis: peer_reviewed（PMID 34289999，个案报告）｜period: 2021 刊出｜geo: universal｜span: 「A 67-year-old man presented with 5 months of worsening memory impairment and sensory gait ataxia on the background of symptomatic anaemia.」「Serum analysis showed normocytic anaemia and leucopenia, severe hypocupraemia, reduced caeruloplasmin and normal zinc levels. Overuse of zinc-containing denture cream was the cause of excess zinc ingestion and resultant copper deficiency, leading to blood dyscrasia and myelopathy.」｜caveat: 单一个案报告，证据等级低；仅用于说明「血锌正常不排除铜缺乏」此一临床注意事项，不作发生率推估
  • F16｜confidence: verified｜basis: peer_reviewed（PMID 34912740，个案报告）｜period: 2021 刊出｜geo: universal｜span: 「We hereby present the case of a 34-year-old female with gastric bypass surgery who presented with neutropenic fever, abdominal pain and diarrhoea, later found to have extended-spectrum beta-lactamase resistant Escherichia coli urinary tract infection and small bowel bacterial overgrowth syndrome, with her anaemia and neutropenia being caused by copper deficiency due to hyperzincaemia induced by using zinc denture adhesive cream.」「Various causes of copper deficiency have been recognized including, but not limited to, malnutrition, gastrectomy, gastric bypass surgery, protein-losing enteropathies (coeliac disease, tropical sprue), Wilson disease and Menkes syndrome.」｜caveat: 单一个案报告；该病人另有多重共病，不能归因於单一因素；本卡仅用于提示高风险人群应先与医师讨论
  • F17｜confidence: verified｜basis: peer_reviewed（PMID 33750997，体外研究）｜period: 2022 刊出｜geo: universal｜span: 「All forms of the adhesives promoted higher biofilm formation when compared to control (P = .003).」「Only Strip showed a change in adhesive strength, with higher values after 3 hours of application (P = .004).」「Daily treatments with mechanical cleaning of the prosthesis are important for removing the adhesives, since the presence of this material can favor biofilm accumulation.」｜caveat: 体外树脂试片研究，非人体临床结果；本卡不引用其所测商品名称与清洁剂品牌之比较结果
  • F18｜confidence: verified｜basis: peer_reviewed（PMID 25643746，体外研究）｜period: 2016 刊出｜geo: universal｜span: 「Cream adhesives were removed more completely after immersion in majority of the denture cleaners than in water. Powder adhesive was removed more quickly than cream adhesives. Cushion adhesive was not removed by immersion in either the denture cleaners or water control.」｜caveat: 体外浸泡实验，未含刷洗步骤；所测为两种膏状、一种粉状、一种垫片型样本，非市售品项全覆盖
  • F19｜confidence: verified｜basis: peer_reviewed（PMID 20733263，体外材料研究）｜period: 2010 刊出｜geo: universal｜span: 「Scant rheological information is available regarding home reliners (liner type denture adhesives).」「They showed a dramatic change in viscoelastic properties and increase in weight after approximately 1 day of water immersion.」「From the viewpoint of dynamic viscoelastic properties and durability, our results indicate that the tested home reliners would not be suitable for improvement of ill-fitting dentures.」｜caveat: 体外材料学研究（测 6 种家用衬垫材），非临床试验；结论限于所测材料之物理性质，未评估临床疗效或黏膜反应
  • F20｜confidence: verified｜basis: peer_reviewed（PMID 39175130，横断面研究，倾向分数配对）｜period: 2024 刊出｜geo: universal（日本受试者）｜span: 「This study included 38 and 40 cream-type adhesive and home-liner users, respectively, and 17 pairs were obtained after propensity-score matching.」「The findings in this study suggest that home liners improve masticatory performance and that participants regularly using cream-type denture adhesives have poorer oral hygiene.」｜caveat: 横断面设计，只能显示相关、不能推论因果；配对后样本仅 17 对
  • F21｜confidence: verified｜basis: peer_reviewed（PMID 32938837，网路问卷调查）｜period: 2020 刊出｜geo: JP（日本假牙配戴者人群调查，非制度陈述）｜span: 「The purpose of this study was to clarify the usage and understanding of denture adhesives among 1,825 denture wearers, aged 40 years and older in Japan, using a web-based survey.」「Results showed that 67.1% of the respondents were satisfied with their dentures; 81.5% of respondents knew about denture adhesive, but only 347 (19.0%) had used the product. Products used by the 347 denture wearers included cream type (79.7%), cushion type (16.2%), and powder type (3.2%). The most common reason for the selection of a particular type was "Saw the product" (59.9%), followed by "Saw an advertisement" (19.3%), and "Explanation at a dental clinic" (8.4%).」「These findings show that denture adhesives were not always necessary for those with ill-fitting dentures.」｜caveat: 封闭式网路调查，样本为线上调查会员，不可视为日本全人口代表性样本；剂型比例仅描述该 347 位使用者
  • F22｜confidence: verified｜basis: peer_reviewed（PMID 36769520，横断面调查）｜period: 2023 刊出｜geo: universal｜span: 「The factors associated with denture adhesive selection were investigated through a face-to-face survey on oral and denture conditions.」「There were 38 and 40 cream-type and home-liner-type adhesive users, respectively.」「The residual ridge conditions and duration of denture use were significant factors in the selection of cream- and home-liner-type denture adhesives.」｜caveat: 受试者限「未定期就诊」之黏著剂使用者；横断面设计、仅显示相关性，不能作为选型建议
  • F23｜confidence: verified｜basis: peer_reviewed（PMID 40127129，随机对照交叉试验，ClinicalTrials.gov NCT05063422）｜period: 2025 刊出｜geo: universal｜span: 「The mean retentive strengths of dentures without adhesive (control) were relatively low across all ridge classifications, ranging from 0.27 to 0.69 lb.」「Furthermore, significant mean differences were observed between ridge classes and the retentive strength of each adhesive product.」｜caveat: 本卡不引用该研究之品牌优劣比较结论，仅引用「未使用黏著剂之基础固位力」与「牙槽嵴分类间存在差异」两项；单位为原文之磅
  • F24｜confidence: verified｜basis: peer_reviewed（PMID 33116029，多中心随机临床试验）｜period: 2021 刊出｜geo: universal（日本 10 中心）｜span: 「Two hundred edentulous subjects who wore complete dentures were allocated to each of the three groups according to denture adhesive type: cream, powder, and control (saline solution). The materials were applied to the mucosal surface of the dentures for 4 days」「OHIP-EDENT-J scores were significantly decreased in all groups after the intervention (p < 0.05); however, there were no statistically significant differences among the groups.」「The cream-type denture adhesives may be expected to improve OHR-QoL in patients with poor residual ridge conditions compared with patients with good residual ridge conditions.」｜caveat: 介入仅 4 天，属短期结果；对照组使用生理食盐水亦显著改善，提示存在非特异性效应，解读单组前后差异时须留意
  • F25｜confidence: verified｜basis: peer_reviewed（PMID 27914670，随机交叉双盲临床试验）｜period: 2017 刊出（同锚：本站 #13 卡 F25）｜geo: universal｜span: 「The masticatory efficacy was significantly higher in dentate participants compared with participants with edentulism who had complete dentures, with or without denture adhesives.」｜caveat: 每组仅 17 人，小样本；该研究另含两款商品之比较，本卡不引用其产品比较结果
  • F26｜confidence: verified｜basis: peer_reviewed（PMID 26553256，交叉临床试验）｜period: 2016 刊出｜geo: universal｜span: 「Assessments were carried out while participants (n=49) wore their dentures first without then with adhesives.」「Stability and retention of conventional dentures ranged initially from good to very good.」「Adhesives significantly decreased OT and DT durations in initially well-fitting complete dentures with fairly well balanced occlusion, and further enhanced denture stability and occlusal contact simultaneity.」｜caveat: 受试者之假牙原本固持与稳定度即良好，结果不可外推至不密合的假牙；本卡引用重点在其人群限定，而非其咬合时间数值
  • F27｜confidence: verified｜basis: peer_reviewed（PMID 40394268，系统性回顾与统合分析）｜period: 2025 刊出｜geo: universal｜span: 「23 studies were included. Only 1 was classified as low risk of bias. Superior masticatory performance was observed in the NAM group rehabilitated with CD (P <.001).」「Clinicians should carefully monitor residual ridge resorption to guide treatment planning and prognosis, particularly in cases of AMs.」｜caveat: 纳入为非随机临床研究，23 篇中仅 1 篇低偏误风险；该回顾比较的是萎缩与非萎缩下颚的预后，未评估黏著剂，本卡仅用于支持「牙槽嵴变化需临床监测」
  • F28｜confidence: verified（摘要逐字取回；全文未能取回）｜basis: clinical_guideline（PMID 21282672，美国补缀学会实证指引）｜period: 2011 刊出｜geo: universal（美国专业团体指引）｜span: 「In 2009, the American College of Prosthodontists (ACP) formed a task force to establish evidence-based guidelines for the care and maintenance of complete dentures. The task force comprised members of the ACP, the Academy of General Dentistry, the American Dental Association Council on Scientific Affairs, the American Dental Hygienists' Association, the National Association of Dental Laboratories and GlaxoSmithKline Consumer Healthcare.」「The task force reviewed synopses of the literature and formulated 15 evidence-based guidelines for denture care and maintenance.」｜caveat: 全文未能取回（付费墙），本卡未引用其 15 条建议之任一条内容，仅引用其存在与专案小组组成；组成中含一家消费保健产品公司，属读者应知的利益关系背景
  • F29｜confidence: verified｜basis: peer_reviewed（PMID 25749085，系统性回顾）｜period: 检索至 2014-03，2015 刊出；非现行最新，效果面已由 F3、F4 较新回顾涵盖｜geo: universal｜span: 「A full text review was carried out for only 32 articles.」「The majority of clinical studies supported the fact that denture adhesives enhance the retention, stability, and masticatory performance of a removable prosthesis. In terms of biocompatibility, long-term in vivo studies to investigate potential harmful effects were lacking.」｜caveat: 检索年代较早，本卡仅引用其「长期人体安全性研究不足」之证据缺口陈述，不引用其效果结论作为现行估计
  • F30｜confidence: verified｜basis: peer_reviewed（PMID 41294516，文献回顾）｜period: 2025 刊出｜geo: universal｜span: 「Studies have shown that denture adhesives may have cytotoxic effects on oral mucosal fibroblasts, as well as on biofilm formation and adhesion. Moreover, there is still little research on the effect of denture adhesives on inflammation of the denture-bearing area and cytokine production.」「The obtained results highlight the need for long-term patient investigations, and thorough clinical trials are absolutely essential to evaluate the actual safety of denture adhesives.」｜caveat: 期刊标示为 Review（非 Systematic Review 出版类型），虽自述采系统性检索流程；本卡引用其安全性证据缺口陈述，不引用为疗效或风险的量化估计
  • F31｜confidence: verified（2026-08-06 以 ego-browser 实载，于分类分级查询资料库以关键字「黏著剂」查得 12 笔，逐笔读取品项名称、鉴别范围与等级栏位）｜basis: official_statement（卫福部食药署委托建置之医疗器材分类分级查询资料库；该资料库连结列于食药署「医疗器材」业务专区）｜period: 2026-08-06 查询现况｜geo: TW｜span: 品項代碼與名稱＝F.3410「氧化乙烯聚合物和/或羧基甲基纖維素鈉假牙黏著劑」（第 1 級）、F.3420「羧甲基纖維素鈉和陽離子聚丙醯胺聚合物假牙黏著劑」（第 3 級）、F.3450「氧化乙烯(環氧乙烷)聚合物和/或梧桐樹膠假牙黏著劑」（第 1 級）、F.3480「聚丙醯胺聚合物(改質的陽離子)假牙黏著劑」（第 3 級）、F.3490「胺基甲基纖維素鈉、和/或聚乙烯甲基醚順丁烯二酸鈣鈉複鹽假牙黏著劑」（第 1 級）、F.3500「聚乙烯甲基醚-順丁烯二酸酐(PVM-MA)酸共聚合物和羧甲基纖維素鈉假牙黏著劑」（第 3 級）；各品項鑑別範圍均載明「用於在假牙放入患者口腔之前塗於假牙基底以增加假牙之固位性和舒適性」｜caveat: 该资料库页面自载「本網站為衛生福利部食品藥物管理署委託建置維護，內容僅供參考，如有差異以衛生福利部食品藥物管理署公告為準」；分类等级以主管机关现行公告为准，本卡不作法规适用判定
  • F32｜confidence: verified（2026-08-06 以 ego-browser 实载全国法规资料库、条文逐字对得上）｜basis: law｜period: 现行条文｜geo: TW｜span: 《醫療器材管理法》第 3 條「本法所稱醫療器材，指儀器、器械、用具、物質、軟體、體外診斷試劑及其相關物品，其設計及使用係以藥理、免疫、代謝或化學以外之方法作用於人體，而達成下列主要功能之一者：一、診斷、治療、緩解或直接預防人類疾病。二、調節或改善人體結構及機能。三、調節生育。」；同法第 25 條「製造、輸入醫療器材，應向中央主管機關申請查驗登記，經核准發給醫療器材許可證後，始得為之。但經中央主管機關公告之品項，其製造、輸入應以登錄方式為之。」｜caveat: 条文引述，非法律意见；个别产品之管理方式（许可证或登录）以主管机关公告为准
  • F33｜confidence: verified（2026-08-06 以 ego-browser 实载，入口页与医疗器材许可证查询页均载入成功，查询表单栏位可见）｜basis: official_statement｜period: 2026-08-06 实测现况｜geo: TW｜span: 衛生福利部食品藥物管理署「西藥、醫療器材及化粧品許可證暨相關資料查詢」網站設有「醫療器材許可證查詢」，查詢欄位包含許可證／登錄字號、中文品名、英文品名、醫療器材主分類、醫療器材商名稱等｜caveat: 入口已验、个别品项未查——该查询须输入验证码，依作业规范不代为破解或自动化查询，本卡未查证任何特定商品之许可证状态；读者需自行查询
  • F34｜confidence: verified（2026-08-06 以 ego-browser 实载全国法规资料库、条文逐字对得上；同锚本站多卡）｜basis: law｜period: 现行条文｜geo: TW｜span: 《醫療法》第 81 條「醫療機構診治病人時，應向病人或其法定代理人、配偶、親屬或關係人告知其病情、治療方針、處置、用藥、預後情形及可能之不良反應。」｜caveat: 条文引述，非法律意见
  • F35｜confidence: verified（2026-08-06 以 ego-browser 实载全国法规资料库、条文逐字对得上；同锚本站多卡）｜basis: law｜period: 现行条文｜geo: TW｜span: 《醫療法》第 87 條「廣告內容暗示或影射醫療業務者，視為醫療廣告。醫學新知或研究報告之發表、病人衛生教育、學術性刊物，未涉及招徠醫療業務者，不視為醫療廣告。」｜caveat: 条文引述，非法律意见；本卡之卫教定位依此条
  • F36｜confidence: verified｜basis: internal_dataset｜period: 2025-03 至 2026-08 GSC｜geo: TW｜span: backlog #31「假牙黏著劑推薦」「假牙黏著劑」「假牙黏著劑可以黏多久」「假牙黏著劑推薦ptt」「假牙黏著劑推薦dcard」5 詞項合計曝光 109,584，單站｜caveat: 曝光为资产级数字、非去重流量；发布转档时本条整条不输出（内部数据不进可见层）
  • F38｜confidence: verified｜basis: peer_reviewed（PMID 38327924，德尔菲法专家共识研究——证据等级属专家意见，低于系统性回顾与临床试验）｜period: 2024 刊出｜geo: universal（印度北马哈拉施特拉邦执业医师）｜span: 「All 31 panellists, chosen randomly, unanimously agreed to participate, with each of them actively involved in all three rounds of the survey. The panellists reached a consensus and definitively concluded that denture adhesives (1) are beneficial for enhancing the fit and comfort of the prosthesis and are not used to mask the underlying denture problems; (2) cause diseases such as denture stomatitis, candidiasis, and resorption of alveolar bone; (3) have the potential for increasing retention, function, and reducing patient anxiety.」｜caveat: 德尔菲共识反映的是31 位受访医师的意见，非量测结果，不能作为因果证据；本卡据实并陈其「造成齿槽骨吸收」之意见，但不将其写成已确立之因果结论。另注：PubMed 另有一篇 1984 年标题涉及黏著剂与骨吸收关系之文献（PMID 6380920），该笔无摘要可取回，本卡未引用其任何内容
  • F39｜confidence: verified｜basis: peer_reviewed（PMID 30123304，交叉随机临床试验）｜period: 2018 刊出｜geo: universal｜span: 「This cross-over randomized clinical trials study was conducted on 90 patients who were wearing well fitted complete dentures. The patients were categorized into three groups based on clinical and radiographic situations of residual ridges.」「Retention, chewing, talking, self-confidence, and efficiency of dentures were improved in all patients. No statistical significant differences in these parameters were observed between the three groups (P > 0.05).」｜caveat: 结果为问卷式主观评估、非仪器量测；本卡仅引用其收案条件（密合良好之假牙）与组间无差异之结果，不引用其结论句中的使用建议
  • F37｜confidence: 结构性整理（编辑框架，非外部事实宣称）｜basis: editorial_framework｜period: 2026-08-06｜geo: universal｜span: 「固持不足／假牙不合」的分流問句、三類劑型的對照架構、以及「該回診而非再加黏著劑」的時機清單，均為本站依 F1 至 F30 文獻整理的溝通用架構｜caveat: 非临床判准、非诊断工具、非分级量表，不取代牙医师检查

来源清单

取用日期均为 2026-08-06；PubMed 条目以 E-utilities efetch（rettype=abstract）取得摘要原文逐字对照，并以 pubtype 及 CommentsCorrections 逐笔检查撤回／勘误／更新关系（30 笔全数无撤回、无勘误、无更新关系）；法规与主管机关页面以 ego-browser 实载并逐字比对。

  1. Papadiochou S, Emmanouil I, Papadiochos I. Denture adhesives: a systematic review. J Prosthet Dent. 2015;113(5):391-397.e2. PMID 25749085
  2. Chen F, Xia Y, Ye C, et al. A systematic review and meta-analysis to evaluate the efficacy of denture adhesives. J Dent. 2021;108:103622. PMID 33727079
  3. Bidra AS 等. Efficacy of denture adhesives in complete denture wearers compared to denture wearers not using denture adhesives. A systematic review. Spec Care Dentist. 2021;41(1):5-13. PMID 33438306
  4. Influence of different presentations of denture adhesives on masticatory function of complete denture wearers: A systematic review and meta-analysis. J Prosthet Dent. 2023;129(6):844-854. PMID 34772484
  5. Comparative effectiveness of types of denture adhesives in enhancing retention and function of complete dentures: a systematic review with network meta-analysis. Clin Oral Investig. 2024;28(1):86. PMID 38183500
  6. Does the use of an adhesive improve conventional complete dentures? A systematic review of randomized controlled trials. J Prosthet Dent. 2022;128(3):301-308. PMID 33551134
  7. Toxicity potential of denture adhesives: A scoping review. J Prosthet Dent. 2022;128(3):335-345. PMID 33888328
  8. Biocompatibility of Denture Adhesives: Effects on Oral Tissues and Inflammatory Responses—Literature Review. Dent J (Basel). 2025;13(11). PMID 41294516
  9. A randomized controlled trial assessing denture adhesive efficacy on denture retention across 13 hours. J Prosthodont. 2024;33(S1). PMID 37805705
  10. Randomized Clinical Study Comparing Three Experimental Denture Adhesives and Fixodent versus No Adhesive. J Clin Dent. 2018;29(3):71-76. PMID 30942961
  11. Iinuma T, Arai Y, Abe Y, et al. Denture wearing during sleep doubles the risk of pneumonia in the very elderly. J Dent Res. 2015;94(3 Suppl):28S-36S. PMID 25294364
  12. Nations SP, Boyer PJ, Love LA, et al. Denture cream: an unusual source of excess zinc, leading to hypocupremia and neurologic disease. Neurology. 2008;71(9):639-643. PMID 18525032
  13. Zinc-Induced Hematologic Toxicities: A Systematic Review of Descriptive Studies. Biol Trace Elem Res. 2026;204(9):6628-6642. PMID 42087025
  14. Hyperzincemia from ingestion of denture adhesives. J Prosthet Dent. 2010;103(6):380-383. PMID 20493327
  15. Hypocupraemia-induced anaemia, sensory ataxia and cognitive impairment secondary to zinc-containing dental adhesive. BMJ Case Rep. 2021;14(7):e242178. PMID 34289999
  16. Acquired Hyperzincaemia Due to Zinc-Laden Denture Adhesives Leading to Hypocupraemia as a Cause of Neutropenia. Eur J Case Rep Intern Med. 2021;8(11):002946. PMID 34912740
  17. Impact of the Physiological Parameters of the Oral Cavity on the Mechanical Properties of Zinc-stabilized and Zinc-free Adhesive Creams: A Comparative In Vitro Study. J Adhes Dent. 2025;27:21-29. PMID 40063077
  18. Effects of Different Forms of Denture Adhesives on Biofilm Formation, Adhesive Strength and Hygiene of Complete Dentures. Int J Prosthodont. 2022;35(4):512-520. PMID 33750997
  19. Evaluation of the efficiency of denture cleaners for removing denture adhesives. Gerodontology. 2016;33(1):101-106. PMID 25643746
  20. Dynamic viscoelastic properties, water absorption, and solubility of home reliners. Dent Mater J. 2010;29(4):440-446. PMID 20733263
  21. Comparison of masticatory performance and oral hygiene status using cream-type denture adhesives and home liners: A cross-sectional study using propensity-score matching. J Oral Rehabil. 2024;51(11):2427-2434. PMID 39175130
  22. A web-based survey of denture adhesive use among denture wearers 40 years of age and older. J Oral Sci. 2020;63(1):98-100. PMID 32938837
  23. Factors Associated with Selection of Denture Adhesive Type: A Cross-Sectional Survey. J Clin Med. 2023;12(3):873. PMID 36769520
  24. Comparative Analysis of Adhesive Retention and Denture Weight in Different Residual Ridge Morphologies: A Cross-Over Randomized-Controlled Trial. Clin Exp Dent Res. 2025;11(2):e70113. PMID 40127129
  25. Multivariate analysis reveals oral health-related quality of life of complete denture wearers with denture adhesives: a multicenter randomized controlled trial. J Prosthodont Res. 2021;65(3):288-294. PMID 33116029
  26. Torres-Sánchez C, Montoya-Salazar V, Torres-Lagares D, Gutierrez-Pérez JL, Jimenez-Castellanos E. Comparison of masticatory efficacy among complete denture wearers with two adhesives and dentate individuals. J Prosthet Dent. 2017;117(5):614-620. PMID 27914670
  27. Influence of denture adhesives on occlusion and disocclusion times. J Prosthet Dent. 2016;116(5):770-777. PMID 26553256
  28. Inflammatory papillary hyperplasia: A systematic review. Med Oral Patol Oral Cir Bucal. 2017;22(1):e36-e42. PMID 27918740
  29. Prognosis of removable complete dentures considering the level of mandibular residual ridge resorption: a systematic review and meta-analysis. Clin Oral Investig. 2025;29(6):318. PMID 40394268
  30. Felton D, Cooper L, Duqum I, et al. Evidence-based guidelines for the care and maintenance of complete dentures: a publication of the American College of Prosthodontists. J Am Dent Assoc. 2011;142 Suppl 1:1S-20S. PMID 21282672
  31. The Assessment of Awareness and Attitudes About the Use of Denture Adhesives Amongst Dental Practitioners in Northern Maharashtra: A Delphi Technique. Cureus. 2024;16(1):e52509. PMID 38327924
  32. The effect of denture adhesive on the efficiency of complete denture in patients with different alveolar ridges. Dent Res J (Isfahan). 2018;15(4):270-274. PMID 30123304
  33. 医疗器械管理法 第 3 条（全国法规资料库）
  34. 医疗器械管理法 第 25 条（全国法规资料库）
  35. 台湾医疗法 第 81 条（全国法规资料库）
  36. 台湾医疗法 第 87 条（全国法规资料库）
  37. 医疗器材分类分级查询资料库（卫生福利部食品药物管理署委托建置维护；连结列于食药署「医疗器材」业务专区）
  38. 卫生福利部食品药物管理署：西药、医疗器材及化粧品许可证暨相关资料查询——医疗器材许可证查询
  39. 内部数据：`analysis/reports/km-dental-backlog.md` #31 附录（词×站×曝光逐笔可对帐）
  40. 编辑框架：本站分流问句、剂型对照与回诊时机清单整理（无外部来源，标示为结构性整理）

内部引用链

  • 可摘义齿本身的费用组成、衬底与修理的收费项目、以及适应期与维护：可摘义齿要多少钱？先分清楚你要做的是哪一种、算的是哪一副（KM-DENTAL-13）——分工声明：可摘义齿的费用、衬底与维护属该卡的 canonical 范围，本卡不重写，只在需要时引用。
  • 固定假牙的分流与报价单读法：做一颗固定假牙要多少钱？（KM-DENTAL-03）
  • 缺牙不补会发生什么、补牙的几条路对照：臼齿拔掉可以不补吗？会怎样？（KM-DENTAL-34）
发布闸门提醒：本卡为 draft。四语（zh-Hans／en／ja）未产前不得进 km_entries；F33 为「入口已验、个别品项未查」之查证管道，发布前如新增任何特定产品之许可证状态，须先完成三件齐查证。

FAQ

假牙黏著剂可以连续黏多久？
**文献量到的是「一次涂抹后十几个小时内效果仍在」，不是「可以连续黏几天」。** 一项 22 人的随机交叉试验在涂抹后 1 至 13 小时的每个时间点量到的咬合力都显著高于未使用黏著剂 [F8]；另一项 48 人的试验在 0.5 至 12 小时的每个时间点也是如此 [F9]。这些是量测期间的上限，不是使用时数的建议。个别产品的用法用量以其核准说明与牙医师指示为准。至于「戴著睡觉」，一项极高龄社区长者的世代研究记录，睡觉时戴假牙与肺炎发生风险相关（风险比 2.38，95% 置信区间 1.25 至 4.56）[F10]，该研究为观察性、人群特定，不能直接外推，但方向上不支持整天不取下的用法。
義歯安定剤は連続してどのくらい保てますか？ — **文献が測ったのは、1 回塗布後の十数時間であって、数日連続の固定ではありません。** 22 人試験では 1–13 時間、48 人試験では 0.5–12 時間の各時点で無使用より咬合力が高い結果でした [F8][F9]。測定期間の上限は使用時間の推奨ではありません。個別製品の用法・用量は承認説明書と歯科医師の指示に従ってください。睡眠中の装着は、平均 87.8 歳の観察研究で肺炎リスクとの関連（HR 2.38、95% 信頼区間 1.25–4.56）がありましたが、因果・一般化はできません [F10]。
How long can denture adhesive hold continuously? — The literature measures effect during a little over ten hours after one application, not continuous adhesion for several days. In a 22-person randomized crossover trial, bite force at every point from 1 to 13 hours after application was significantly higher than without adhesive [F8]; the same was true at every point from 0.5 to 12 hours in a 48-person trial [F9]. These are observation-period ceilings, not recommended hours of use. Use and dosage for individual products follow their approved instructions and the dentist’s directions. For sleeping with dentures, a cohort study of very old community-dwelling adults associated sleep-time wearing with pneumonia risk (hazard ratio 2.38, 95% confidence interval 1.25 to 4.56) [F10]. It is observational and population-specific and cannot be directly generalized, but its direction does not support never removing dentures all day.
膏状、粉状、垫片型，哪一种比较好？
**文献的答案是「多数比较没有差异」，而不是某一种比较好。** 纳入 9 篇临床研究的统合分析显示，膏状与粉状在咀嚼表现上没有差异、膏状与贴片型在咬合力上没有差异；只有在牙槽嵴吸收明显者，膏状的咀嚼表现高于贴片型，而粉状的咬合力高于贴片型——且所有结果的证据确定性都是极低 [F5]。实际适合哪一型，与牙槽嵴条件、配戴时间等因素相关 [F22]，须由牙医师依你的口腔状况判断。本卡不推荐任何品牌或商品。
クリーム、パウダー、クッション型のどれがよいですか？ — **多くの比較で差がない、というのが文献の答えです。** 顎堤吸収が著しい一部の人で差がありましたが、全結果の確実性は非常に低いです [F5]。顎堤状態や装着期間も関係するため [F22]、口腔内を診て歯科医師が判断します。ブランド・製品の推奨はしません。
Is cream, powder, or cushion form better? — The literature’s answer is that most comparisons found no difference, not that one form is better. A meta-analysis of 9 clinical studies found no cream–powder difference in masticatory performance and no cream–strip difference in occlusal force. Only in people with marked residual-ridge resorption did cream have higher masticatory performance than strips and powder higher occlusal force than strips—and certainty for every result was very low [F5]. Which form is appropriate is associated with factors such as residual-ridge condition and wearing duration [F22] and needs a dentist’s judgment from your oral condition. This guide recommends no brand or product.
我的假牙松了，多用一点黏著剂撑著可以吗？
**不建议，而且这是本卡想讲的重点。** 黏著剂毒性范畴回顾的结论句把「使用贴合良好的可摘义齿、适当回诊追踪、正确的使用指示」列为优先 [F1]；一项测试家用衬垫材的研究结论写明，这类材料从黏弹性与耐久性的角度看，不适合用于改善不密合的假牙 [F19]；台湾主管机关品项表对假牙黏著剂写的用途，也只写到「增加假牙之固位性和舒适性」[F31]。此外，持续使用不密合的假牙是黏膜病变的常见风险因子 [F2]，而「愈用愈多」正是锌过量个案的典型情境 [F11][F12]。假牙松动请回诊检查，由牙医师判断要调整、衬底还是重做。
義歯がゆるいとき、安定剤を多く使ってしのげますか？ — **勧めません。** 適合のよい義歯、フォローアップ、正しい使用説明が優先です [F1]。家庭用リライナーは不適合義歯改善に適さないとされ [F19]、台湾の品目用途も維持と快適性の増加に限られます [F31]。不適合義歯の継続使用は粘膜病変のリスク因子で [F2]、使用量が増え続ける状況は亜鉛過量症例の典型です [F11][F12]。
My denture is loose. Can I use more adhesive to keep it going? — It is not recommended. The scoping review’s conclusion prioritizes well-adapted removable dentures, appropriate follow-up, and correct instructions [F1]. A study of home reliners concluded that, in terms of viscoelasticity and durability, they are not suitable for improving ill-fitting dentures [F19]. Taiwan’s authority item list also states the purpose only as increasing denture retention and comfort [F31]. Continued use of an ill-fitting denture is a common risk factor for mucosal lesions [F2], and “needing more and more” is the typical context of zinc-overuse cases [F11][F12]. If the denture is loose, return for examination so a dentist can decide on adjustment, relining, or remaking.

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km 編輯部・《假牙黏著剂怎么选？可以黏多久？｜證據鏈》・IDAEO 知識庫・2026-08-13・https://km.idaeo.ai/reports/dental-denture-adhesive-evidence

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更新 2026-08-13T14:17:40.728Z · server-rendered · four-language · IDAEO 知識庫