km.idaeo.ai · IDAEO 知識庫

🏛 本文屬於主題館「reports」 →

假牙黏著劑怎麼選？可以黏多久？｜證據鏈

km 編輯部2026-08-13閱讀約 70 分鐘
#證據鏈#牙醫KM#假牙#口腔健康

本頁是〈假牙黏著劑怎麼選？可以黏多久？〉的事實單元帳：每一條主張對應的來源、證據等級、地域與期間、原文引句與限制，逐條攤開。

假牙黏著劑怎麼選？可以黏多久？｜證據鏈

F-Units（事實單元帳）

  • F1｜confidence: verified｜basis: peer_reviewed（PMID 33888328，範疇回顧 scoping review）｜period: 檢索 2020-10，2022 刊出｜geo: universal｜span: 「Commercially available denture adhesives have a dose-dependent cytotoxic effect on fibroblasts and keratinocytes, with poor cell recovery noted in older human fibroblasts. Patients presented different levels of neurologic or hematological alterations associated with the excessive use of denture adhesives.」「Most commercially available denture adhesives have a dose-dependent cytotoxic effect, and the use of well-adapted removable dental prostheses, proper patient follow-ups, and correct instructions for their use when indicated should be a priority.」｜caveat: 範疇回顧不作療效或安全性的統合估計，僅描繪文獻地圖；納入 33 篇（14 篇體外、19 篇臨床）
  • F2｜confidence: verified｜basis: peer_reviewed（PMID 27918740，系統性回顧）｜period: 檢索 2005-01 至 2015-10，2017 刊出｜geo: universal｜span: 「Out of the 190 studies obtained initially from the search 16 articles were selected to be included in our systematic review. The prevalence of denture stomatitis was 29.56% and 4.44% for IPH.」「Smoking and continued use of ill-fitting dentures turned out to be the most frequent risk factors for developing IPH.」｜caveat: 盛行率為納入研究的合併描述、非人口普查；本卡引用其風險因子敘述，不作因果推論；該回顧未評估黏著劑
  • F3｜confidence: verified｜basis: peer_reviewed（PMID 33727079，系統性回顧與統合分析）｜period: 檢索至 2020-03，2021 刊出；非現行檢索日期最新者，較新者見 F4（檢索至 2023-07）｜geo: universal｜span: 「Of the 1729 records identified, 39 studies (43 articles) were included in the analysis. Among them, 23 were RCTs and 16 were CCTs, with two multicenter clinical trials (1 RCT and 1 CCT). Meta-analysis results indicated that DAs provided significantly higher retention (SMD 1.34, 95 % CI: 0.89-1.79, P < 0.001) for CDs. Bite force (SMD 0.98, 95 % CI: 0.50-1.47, P < 0.001) and masticatory performance (SMD 0.72, 95 % CI: 0.23-1.22, P = 0.004) of the CD wearers were also improved after using DAs, but the effect size was relatively smaller.」｜caveat: 納入含非隨機對照試驗；效果量為標準化平均差，不可換算成個人可感受的改善幅度
  • F4｜confidence: verified｜basis: peer_reviewed（PMID 38183500，系統性回顧與網絡統合分析，PROSPERO CRD42023451045）｜period: 檢索自資料庫建立至 2023-07，2024 刊出＝本卡納入之黏著劑效果回顧中檢索日期較新者（2026-08-06 以 PubMed 對 "denture adhesive"[tiab] 併 systematic[sb] 重查 12 筆，未見檢索日期更新者）｜geo: universal｜span: 「Seventeen articles were included in the quantitative analysis. Cream denture adhesives significantly increased bite force in both incisal region (RR = 7.63[95%CI: 3.34, 11.91]) (P < .05) as well as premolar and molar regions (RR = 33.66[95%CI: 15.15, 52.16]).」「Powder adhesives significantly increased premolar and molar bite force (RR = 36.00[95%CI: 16.20, 55.79]) (P < .05) and Kapur's index of retention (mandibular denture) (RR = 1.54[95%CI: 0.58, 2.49]) (P = 0.002).」「Cream and powder denture adhesives are effective in enhancing the retention of mandibular dentures (Kapur's index) and bite force in the premolar/molar region in complete denture wearers (moderate level of certainty of evidence).」｜caveat: 網絡統合分析含間接比較，排名（SUCRA）本卡不引用；效果指標為研究情境下的量測值，非個人預期值
  • F5｜confidence: verified｜basis: peer_reviewed（PMID 34772484，系統性回顧與統合分析）｜period: 檢索至 2021-07，2023 刊出｜geo: universal｜span: 「Nine studies (6 randomized and 3 nonrandomized clinical trials) were included. The risk of bias was considered moderate. Meta-analyses showed no differences between cream and powder denture adhesives for masticatory performance (standard mean difference=0.02; 95% CI=-0.46 to 0.50, P=.93) or between cream and strip denture adhesives for occlusal force (mean difference=14.35; 95% CI=-11.14 to 39.84, P=.27).」「However, for resorbed ridges, cream denture adhesive resulted in a higher masticatory performance than strip (P<.05). When comparing powder to strip denture adhesives, the occlusal force was higher in the powder group (P<.05). The certainty of evidence was very low for all evaluated outcomes.」｜caveat: 次族群結果（齒槽脊吸收者）來自質性分析、非統合估計，證據確定性極低，不可作為選型準則
  • F6｜confidence: verified｜basis: peer_reviewed（PMID 33438306，系統性回顧）｜period: 檢索自資料庫建立至 2020-02-06，2021 刊出｜geo: universal｜span: 「A total of 497 abstracts were reviewed, resulting in inclusion of 10 RCTs.」「All 10 studies were assessed at unclear (10%) or high risk of bias (90%).」「Due to the heterogeneity of the outcomes, unclear/high risk of bias and small sample sizes, the quality of the evidence was very low.」｜caveat: 僅收雙顎全口假牙的隨機對照試驗，不涵蓋局部活動假牙
  • F7｜confidence: verified｜basis: peer_reviewed（PMID 33551134，系統性回顧）｜period: 檢索至 2020-10，2022 刊出｜geo: universal｜span: 「Thirteen studies were included with a total of 516 participants with a mean age of 65.5 years.」「Most studies presented a low risk of bias, but the certainty of the evidence was classified as low to moderate.」｜caveat: 與 F6 對偏誤風險的評估結論不一致（一份評為多數低偏誤、一份評為 90% 高偏誤），本卡並列不擇一
  • F8｜confidence: verified｜basis: peer_reviewed（PMID 37805705，隨機對照交叉試驗）｜period: 2024 刊出｜geo: universal｜span: 「Twenty-two participants with a fair-to-poor fitting maxillary denture opposed by natural dentition or a stable mandibular denture were enrolled in this single-center, randomized, double-blind, two-treatment, 4-period crossover study.」「bite force measurements were retaken at 1, 3, 5, 7, 9, 11, and 13 h.」「There were 15 females and 7 males with a mean age of 70 years.」「Both adhesives showed a statistically significant increase in bite force (p < 0.001) at each time point compared to no adhesive.」｜caveat: 單中心、22 人、廠商配方比較試驗；本卡不引用其兩款產品之優劣比較結論，僅引用「相對於未使用黏著劑」的時間點結果；13 小時為量測期上限，非使用時數建議
  • F9｜confidence: verified｜basis: peer_reviewed（PMID 30942961，隨機對照交叉試驗）｜period: 2018 刊出｜geo: universal｜span: 「aimed to compare three experimental adhesives ("Adhesive 1," "Adhesive 2," "Adhesive 3") with slightly different formulations and a commercially marketed "Positive control" with a "No Adhesive" arm using incisal bite force measurements over 12 hours in subjects with a moderately well- to well-fitting maxillary denture.」「This procedure was repeated at 0.5, 1, 3, 6, 9, and 12 hours after adhesive application」「A total of 48 subjects completed the study. All experimental formulations showed statistically significantly higher bite force measurements compared to the No Adhesive arm at all time points」｜caveat: 受試者為密合度中等偏佳至良好之上顎假牙者；本卡不引用其產品間比較結論；12 小時為量測期上限
  • F10｜confidence: verified｜basis: peer_reviewed（PMID 25294364，前瞻世代研究）｜period: 3 年追蹤，2015 刊出｜geo: universal（日本社區長者世代，非制度陳述）｜span: 「At baseline, 524 randomly selected seniors (228 men and 296 women; mean age, 87.8 years) were examined for oral health status and oral hygiene behaviors」「During a 3-year follow-up period, 48 events associated with pneumonia (20 deaths and 28 acute hospitalizations) were identified. Among 453 denture wearers, 186 (40.8%) who wore their dentures during sleep were at higher risk for pneumonia than those who removed their dentures at night (log rank P = 0.021).」「for denture wearing during sleep, HR, 2.38; and 95% CI, 1.25-4.56」「those who wore dentures during sleep were more likely to have tongue and denture plaque, gum inflammation, positive culture for Candida albicans, and higher levels of circulating interleukin-6 as compared with their counterparts.」｜caveat: 觀察性研究，僅能顯示相關而非因果；族群為平均 87.8 歲之社區極高齡者，不可外推至一般成人；該研究未直接評估黏著劑
  • F11｜confidence: verified｜basis: peer_reviewed（PMID 18525032，個案系列）｜period: 2008 刊出｜geo: universal｜span: 「We identified four patients, one previously reported, with various neurologic abnormalities in the setting of hypocupremia and hyperzincemia. Each of these patients wore dentures and used very large amounts of denture cream chronically.」「Zinc concentrations ranging from about 17,000 to 34,000 mug/g were identified in…denture creams.」「Denture cream contains zinc, and chronic excessive use may result in hypocupremia and serious neurologic disease.」｜caveat: 個案系列（n=4），證據等級低於對照研究；span 以 … 省略原文中的商品名，本卡不列任何品牌；所測樣本為 2008 年當時之產品，不代表現售產品之含鋅量
  • F12｜confidence: verified｜basis: peer_reviewed（PMID 42087025，系統性回顧）｜period: 收錄 1972 至 2025 年個案，2026 刊出＝本卡鋅毒性面向檢索日期最新者｜geo: universal｜span: 「Thirty-four publications describing 37 individual cases were included, spanning from 1972 to 2025. Zinc exposure most commonly resulted from oral supplements, denture adhesive creams, and coin ingestion, with reported daily elemental zinc doses ranging from approximately 50 mg to more than 1500 mg and exposure durations ranging from weeks to years.」「Serum copper levels were reduced in all patients.」「Discontinuation of zinc exposure with copper supplementation resulted in hematologic recovery in the majority of cases, typically within weeks to months, while neurological manifestations improved more slowly and were sometimes incomplete.」｜caveat: 納入者為描述性研究與個案報告，屬罕見事件之彙整，不能用來估計使用者的發生率；每日鋅劑量範圍涵蓋所有暴露來源，非單指黏著劑
  • F13｜confidence: verified｜basis: peer_reviewed（PMID 20493327，文獻回顧）｜period: 2010 刊出｜geo: universal｜span: 「This condition causes elevation of serum zinc levels that result in depression of serum copper. The low serum copper levels cause bone marrow depression and widespread sensory and motor neuropathies.」「Denture patients must be advised of the risks of prolonged overuse of denture adhesives.」｜caveat: 敘述性回顧、非系統性回顧；刊出於 2010 年，較新的彙整見 F12
  • F14｜confidence: verified｜basis: peer_reviewed（PMID 40063077，體外比較研究）｜period: 2025 刊出｜geo: universal｜span: 「The current trend in denture adhesives is shifting toward zinc-free formulations due to the significant health concerns associated with zinc.」｜caveat: 本卡僅引用其背景段落對配方趨勢的陳述，未引用其流變學結果；此為研究者陳述，非市場普查或主管機關統計；個別產品是否含鋅仍以該產品成分標示為準
  • F15｜confidence: verified｜basis: peer_reviewed（PMID 34289999，個案報告）｜period: 2021 刊出｜geo: universal｜span: 「A 67-year-old man presented with 5 months of worsening memory impairment and sensory gait ataxia on the background of symptomatic anaemia.」「Serum analysis showed normocytic anaemia and leucopenia, severe hypocupraemia, reduced caeruloplasmin and normal zinc levels. Overuse of zinc-containing denture cream was the cause of excess zinc ingestion and resultant copper deficiency, leading to blood dyscrasia and myelopathy.」｜caveat: 單一個案報告，證據等級低；僅用於說明「血鋅正常不排除銅缺乏」此一臨床注意事項，不作發生率推估
  • F16｜confidence: verified｜basis: peer_reviewed（PMID 34912740，個案報告）｜period: 2021 刊出｜geo: universal｜span: 「We hereby present the case of a 34-year-old female with gastric bypass surgery who presented with neutropenic fever, abdominal pain and diarrhoea, later found to have extended-spectrum beta-lactamase resistant Escherichia coli urinary tract infection and small bowel bacterial overgrowth syndrome, with her anaemia and neutropenia being caused by copper deficiency due to hyperzincaemia induced by using zinc denture adhesive cream.」「Various causes of copper deficiency have been recognized including, but not limited to, malnutrition, gastrectomy, gastric bypass surgery, protein-losing enteropathies (coeliac disease, tropical sprue), Wilson disease and Menkes syndrome.」｜caveat: 單一個案報告；該病人另有多重共病，不能歸因於單一因素；本卡僅用於提示高風險族群應先與醫師討論
  • F17｜confidence: verified｜basis: peer_reviewed（PMID 33750997，體外研究）｜period: 2022 刊出｜geo: universal｜span: 「All forms of the adhesives promoted higher biofilm formation when compared to control (P = .003).」「Only Strip showed a change in adhesive strength, with higher values after 3 hours of application (P = .004).」「Daily treatments with mechanical cleaning of the prosthesis are important for removing the adhesives, since the presence of this material can favor biofilm accumulation.」｜caveat: 體外樹脂試片研究，非人體臨床結果；本卡不引用其所測商品名稱與清潔劑品牌之比較結果
  • F18｜confidence: verified｜basis: peer_reviewed（PMID 25643746，體外研究）｜period: 2016 刊出｜geo: universal｜span: 「Cream adhesives were removed more completely after immersion in majority of the denture cleaners than in water. Powder adhesive was removed more quickly than cream adhesives. Cushion adhesive was not removed by immersion in either the denture cleaners or water control.」｜caveat: 體外浸泡實驗，未含刷洗步驟；所測為兩種膏狀、一種粉狀、一種墊片型樣本，非市售品項全覆蓋
  • F19｜confidence: verified｜basis: peer_reviewed（PMID 20733263，體外材料研究）｜period: 2010 刊出｜geo: universal｜span: 「Scant rheological information is available regarding home reliners (liner type denture adhesives).」「They showed a dramatic change in viscoelastic properties and increase in weight after approximately 1 day of water immersion.」「From the viewpoint of dynamic viscoelastic properties and durability, our results indicate that the tested home reliners would not be suitable for improvement of ill-fitting dentures.」｜caveat: 體外材料學研究（測 6 種家用襯墊材），非臨床試驗；結論限於所測材料之物理性質，未評估臨床療效或黏膜反應
  • F20｜confidence: verified｜basis: peer_reviewed（PMID 39175130，橫斷面研究，傾向分數配對）｜period: 2024 刊出｜geo: universal（日本受試者）｜span: 「This study included 38 and 40 cream-type adhesive and home-liner users, respectively, and 17 pairs were obtained after propensity-score matching.」「The findings in this study suggest that home liners improve masticatory performance and that participants regularly using cream-type denture adhesives have poorer oral hygiene.」｜caveat: 橫斷面設計，只能顯示相關、不能推論因果；配對後樣本僅 17 對
  • F21｜confidence: verified｜basis: peer_reviewed（PMID 32938837，網路問卷調查）｜period: 2020 刊出｜geo: JP（日本假牙配戴者族群調查，非制度陳述）｜span: 「The purpose of this study was to clarify the usage and understanding of denture adhesives among 1,825 denture wearers, aged 40 years and older in Japan, using a web-based survey.」「Results showed that 67.1% of the respondents were satisfied with their dentures; 81.5% of respondents knew about denture adhesive, but only 347 (19.0%) had used the product. Products used by the 347 denture wearers included cream type (79.7%), cushion type (16.2%), and powder type (3.2%). The most common reason for the selection of a particular type was "Saw the product" (59.9%), followed by "Saw an advertisement" (19.3%), and "Explanation at a dental clinic" (8.4%).」「These findings show that denture adhesives were not always necessary for those with ill-fitting dentures.」｜caveat: 封閉式網路調查，樣本為線上調查會員，不可視為日本全人口代表性樣本；劑型比例僅描述該 347 位使用者
  • F22｜confidence: verified｜basis: peer_reviewed（PMID 36769520，橫斷面調查）｜period: 2023 刊出｜geo: universal｜span: 「The factors associated with denture adhesive selection were investigated through a face-to-face survey on oral and denture conditions.」「There were 38 and 40 cream-type and home-liner-type adhesive users, respectively.」「The residual ridge conditions and duration of denture use were significant factors in the selection of cream- and home-liner-type denture adhesives.」｜caveat: 受試者限「未定期就診」之黏著劑使用者；橫斷面設計、僅顯示相關性，不能作為選型建議
  • F23｜confidence: verified｜basis: peer_reviewed（PMID 40127129，隨機對照交叉試驗，ClinicalTrials.gov NCT05063422）｜period: 2025 刊出｜geo: universal｜span: 「The mean retentive strengths of dentures without adhesive (control) were relatively low across all ridge classifications, ranging from 0.27 to 0.69 lb.」「Furthermore, significant mean differences were observed between ridge classes and the retentive strength of each adhesive product.」｜caveat: 本卡不引用該研究之品牌優劣比較結論，僅引用「未使用黏著劑之基礎固持力」與「齒槽脊分類間存在差異」兩項；單位為原文之磅
  • F24｜confidence: verified｜basis: peer_reviewed（PMID 33116029，多中心隨機臨床試驗）｜period: 2021 刊出｜geo: universal（日本 10 中心）｜span: 「Two hundred edentulous subjects who wore complete dentures were allocated to each of the three groups according to denture adhesive type: cream, powder, and control (saline solution). The materials were applied to the mucosal surface of the dentures for 4 days」「OHIP-EDENT-J scores were significantly decreased in all groups after the intervention (p < 0.05); however, there were no statistically significant differences among the groups.」「The cream-type denture adhesives may be expected to improve OHR-QoL in patients with poor residual ridge conditions compared with patients with good residual ridge conditions.」｜caveat: 介入僅 4 天，屬短期結果；對照組使用生理食鹽水亦顯著改善，提示存在非特異性效應，解讀單組前後差異時須留意
  • F25｜confidence: verified｜basis: peer_reviewed（PMID 27914670，隨機交叉雙盲臨床試驗）｜period: 2017 刊出（同錨：本站 #13 卡 F25）｜geo: universal｜span: 「The masticatory efficacy was significantly higher in dentate participants compared with participants with edentulism who had complete dentures, with or without denture adhesives.」｜caveat: 每組僅 17 人，小樣本；該研究另含兩款商品之比較，本卡不引用其產品比較結果
  • F26｜confidence: verified｜basis: peer_reviewed（PMID 26553256，交叉臨床試驗）｜period: 2016 刊出｜geo: universal｜span: 「Assessments were carried out while participants (n=49) wore their dentures first without then with adhesives.」「Stability and retention of conventional dentures ranged initially from good to very good.」「Adhesives significantly decreased OT and DT durations in initially well-fitting complete dentures with fairly well balanced occlusion, and further enhanced denture stability and occlusal contact simultaneity.」｜caveat: 受試者之假牙原本固持與穩定度即良好，結果不可外推至不密合的假牙；本卡引用重點在其族群限定，而非其咬合時間數值
  • F27｜confidence: verified｜basis: peer_reviewed（PMID 40394268，系統性回顧與統合分析）｜period: 2025 刊出｜geo: universal｜span: 「23 studies were included. Only 1 was classified as low risk of bias. Superior masticatory performance was observed in the NAM group rehabilitated with CD (P <.001).」「Clinicians should carefully monitor residual ridge resorption to guide treatment planning and prognosis, particularly in cases of AMs.」｜caveat: 納入為非隨機臨床研究，23 篇中僅 1 篇低偏誤風險；該回顧比較的是萎縮與非萎縮下顎的預後，未評估黏著劑，本卡僅用於支持「齒槽脊變化需臨床監測」
  • F28｜confidence: verified（摘要逐字取回；全文未能取回）｜basis: clinical_guideline（PMID 21282672，美國補綴學會實證指引）｜period: 2011 刊出｜geo: universal（美國專業團體指引）｜span: 「In 2009, the American College of Prosthodontists (ACP) formed a task force to establish evidence-based guidelines for the care and maintenance of complete dentures. The task force comprised members of the ACP, the Academy of General Dentistry, the American Dental Association Council on Scientific Affairs, the American Dental Hygienists' Association, the National Association of Dental Laboratories and GlaxoSmithKline Consumer Healthcare.」「The task force reviewed synopses of the literature and formulated 15 evidence-based guidelines for denture care and maintenance.」｜caveat: 全文未能取回（付費牆），本卡未引用其 15 條建議之任一條內容，僅引用其存在與專案小組組成；組成中含一家消費保健產品公司，屬讀者應知的利益關係背景
  • F29｜confidence: verified｜basis: peer_reviewed（PMID 25749085，系統性回顧）｜period: 檢索至 2014-03，2015 刊出；非現行最新，效果面已由 F3、F4 較新回顧涵蓋｜geo: universal｜span: 「A full text review was carried out for only 32 articles.」「The majority of clinical studies supported the fact that denture adhesives enhance the retention, stability, and masticatory performance of a removable prosthesis. In terms of biocompatibility, long-term in vivo studies to investigate potential harmful effects were lacking.」｜caveat: 檢索年代較早，本卡僅引用其「長期人體安全性研究不足」之證據缺口陳述，不引用其效果結論作為現行估計
  • F30｜confidence: verified｜basis: peer_reviewed（PMID 41294516，文獻回顧）｜period: 2025 刊出｜geo: universal｜span: 「Studies have shown that denture adhesives may have cytotoxic effects on oral mucosal fibroblasts, as well as on biofilm formation and adhesion. Moreover, there is still little research on the effect of denture adhesives on inflammation of the denture-bearing area and cytokine production.」「The obtained results highlight the need for long-term patient investigations, and thorough clinical trials are absolutely essential to evaluate the actual safety of denture adhesives.」｜caveat: 期刊標示為 Review（非 Systematic Review 出版類型），雖自述採系統性檢索流程；本卡引用其安全性證據缺口陳述，不引用為療效或風險的量化估計
  • F31｜confidence: verified（2026-08-06 以 ego-browser 實載，於分類分級查詢資料庫以關鍵字「黏著劑」查得 12 筆，逐筆讀取品項名稱、鑑別範圍與等級欄位）｜basis: official_statement（衛福部食藥署委託建置之醫療器材分類分級查詢資料庫；該資料庫連結列於食藥署「醫療器材」業務專區）｜period: 2026-08-06 查詢現況｜geo: TW｜span: 品項代碼與名稱＝F.3410「氧化乙烯聚合物和/或羧基甲基纖維素鈉假牙黏著劑」（第 1 級）、F.3420「羧甲基纖維素鈉和陽離子聚丙醯胺聚合物假牙黏著劑」（第 3 級）、F.3450「氧化乙烯(環氧乙烷)聚合物和/或梧桐樹膠假牙黏著劑」（第 1 級）、F.3480「聚丙醯胺聚合物(改質的陽離子)假牙黏著劑」（第 3 級）、F.3490「胺基甲基纖維素鈉、和/或聚乙烯甲基醚順丁烯二酸鈣鈉複鹽假牙黏著劑」（第 1 級）、F.3500「聚乙烯甲基醚-順丁烯二酸酐(PVM-MA)酸共聚合物和羧甲基纖維素鈉假牙黏著劑」（第 3 級）；各品項鑑別範圍均載明「用於在假牙放入患者口腔之前塗於假牙基底以增加假牙之固持性和舒適性」｜caveat: 該資料庫頁面自載「本網站為衛生福利部食品藥物管理署委託建置維護，內容僅供參考，如有差異以衛生福利部食品藥物管理署公告為準」；分類等級以主管機關現行公告為準，本卡不作法規適用判定
  • F32｜confidence: verified（2026-08-06 以 ego-browser 實載全國法規資料庫、條文逐字對得上）｜basis: law｜period: 現行條文｜geo: TW｜span: 《醫療器材管理法》第 3 條「本法所稱醫療器材，指儀器、器械、用具、物質、軟體、體外診斷試劑及其相關物品，其設計及使用係以藥理、免疫、代謝或化學以外之方法作用於人體，而達成下列主要功能之一者：一、診斷、治療、緩解或直接預防人類疾病。二、調節或改善人體結構及機能。三、調節生育。」；同法第 25 條「製造、輸入醫療器材，應向中央主管機關申請查驗登記，經核准發給醫療器材許可證後，始得為之。但經中央主管機關公告之品項，其製造、輸入應以登錄方式為之。」｜caveat: 條文引述，非法律意見；個別產品之管理方式（許可證或登錄）以主管機關公告為準
  • F33｜confidence: verified（2026-08-06 以 ego-browser 實載，入口頁與醫療器材許可證查詢頁均載入成功，查詢表單欄位可見）｜basis: official_statement｜period: 2026-08-06 實測現況｜geo: TW｜span: 衛生福利部食品藥物管理署「西藥、醫療器材及化粧品許可證暨相關資料查詢」網站設有「醫療器材許可證查詢」，查詢欄位包含許可證／登錄字號、中文品名、英文品名、醫療器材主分類、醫療器材商名稱等｜caveat: 入口已驗、個別品項未查——該查詢須輸入驗證碼，依作業規範不代為破解或自動化查詢，本卡未查證任何特定商品之許可證狀態；讀者需自行查詢
  • F34｜confidence: verified（2026-08-06 以 ego-browser 實載全國法規資料庫、條文逐字對得上；同錨本站多卡）｜basis: law｜period: 現行條文｜geo: TW｜span: 《醫療法》第 81 條「醫療機構診治病人時，應向病人或其法定代理人、配偶、親屬或關係人告知其病情、治療方針、處置、用藥、預後情形及可能之不良反應。」｜caveat: 條文引述，非法律意見
  • F35｜confidence: verified（2026-08-06 以 ego-browser 實載全國法規資料庫、條文逐字對得上；同錨本站多卡）｜basis: law｜period: 現行條文｜geo: TW｜span: 《醫療法》第 87 條「廣告內容暗示或影射醫療業務者，視為醫療廣告。醫學新知或研究報告之發表、病人衛生教育、學術性刊物，未涉及招徠醫療業務者，不視為醫療廣告。」｜caveat: 條文引述，非法律意見；本卡之衛教定位依此條
  • F36｜confidence: verified｜basis: internal_dataset｜period: 2025-03 至 2026-08 GSC｜geo: TW｜span: backlog #31「假牙黏著劑推薦」「假牙黏著劑」「假牙黏著劑可以黏多久」「假牙黏著劑推薦ptt」「假牙黏著劑推薦dcard」5 詞項合計曝光 109,584，單站｜caveat: 曝光為資產級數字、非去重流量；發布轉檔時本條整條不輸出（內部數據不進可見層）
  • F38｜confidence: verified｜basis: peer_reviewed（PMID 38327924，德爾菲法專家共識研究——證據等級屬專家意見，低於系統性回顧與臨床試驗）｜period: 2024 刊出｜geo: universal（印度北馬哈拉施特拉邦執業醫師）｜span: 「All 31 panellists, chosen randomly, unanimously agreed to participate, with each of them actively involved in all three rounds of the survey. The panellists reached a consensus and definitively concluded that denture adhesives (1) are beneficial for enhancing the fit and comfort of the prosthesis and are not used to mask the underlying denture problems; (2) cause diseases such as denture stomatitis, candidiasis, and resorption of alveolar bone; (3) have the potential for increasing retention, function, and reducing patient anxiety.」｜caveat: 德爾菲共識反映的是31 位受訪醫師的意見，非量測結果，不能作為因果證據；本卡據實併陳其「造成齒槽骨吸收」之意見，但不將其寫成已確立之因果結論。另註：PubMed 另有一篇 1984 年標題涉及黏著劑與骨吸收關係之文獻（PMID 6380920），該筆無摘要可取回，本卡未引用其任何內容
  • F39｜confidence: verified｜basis: peer_reviewed（PMID 30123304，交叉隨機臨床試驗）｜period: 2018 刊出｜geo: universal｜span: 「This cross-over randomized clinical trials study was conducted on 90 patients who were wearing well fitted complete dentures. The patients were categorized into three groups based on clinical and radiographic situations of residual ridges.」「Retention, chewing, talking, self-confidence, and efficiency of dentures were improved in all patients. No statistical significant differences in these parameters were observed between the three groups (P > 0.05).」｜caveat: 結果為問卷式主觀評估、非儀器量測；本卡僅引用其收案條件（密合良好之假牙）與組間無差異之結果，不引用其結論句中的使用建議
  • F37｜confidence: 結構性整理（編輯框架，非外部事實宣稱）｜basis: editorial_framework｜period: 2026-08-06｜geo: universal｜span: 「固持不足／假牙不合」的分流問句、三類劑型的對照架構、以及「該回診而非再加黏著劑」的時機清單，均為本站依 F1 至 F30 文獻整理的溝通用架構｜caveat: 非臨床判準、非診斷工具、非分級量表，不取代牙醫師檢查

來源清單

取用日期均為 2026-08-06；PubMed 條目以 E-utilities efetch（rettype=abstract）取得摘要原文逐字對照，並以 pubtype 及 CommentsCorrections 逐筆檢查撤回／勘誤／更新關係（30 筆全數無撤回、無勘誤、無更新關係）；法規與主管機關頁面以 ego-browser 實載並逐字比對。

  1. Papadiochou S, Emmanouil I, Papadiochos I. Denture adhesives: a systematic review. J Prosthet Dent. 2015;113(5):391-397.e2. PMID 25749085
  2. Chen F, Xia Y, Ye C, et al. A systematic review and meta-analysis to evaluate the efficacy of denture adhesives. J Dent. 2021;108:103622. PMID 33727079
  3. Bidra AS 等. Efficacy of denture adhesives in complete denture wearers compared to denture wearers not using denture adhesives. A systematic review. Spec Care Dentist. 2021;41(1):5-13. PMID 33438306
  4. Influence of different presentations of denture adhesives on masticatory function of complete denture wearers: A systematic review and meta-analysis. J Prosthet Dent. 2023;129(6):844-854. PMID 34772484
  5. Comparative effectiveness of types of denture adhesives in enhancing retention and function of complete dentures: a systematic review with network meta-analysis. Clin Oral Investig. 2024;28(1):86. PMID 38183500
  6. Does the use of an adhesive improve conventional complete dentures? A systematic review of randomized controlled trials. J Prosthet Dent. 2022;128(3):301-308. PMID 33551134
  7. Toxicity potential of denture adhesives: A scoping review. J Prosthet Dent. 2022;128(3):335-345. PMID 33888328
  8. Biocompatibility of Denture Adhesives: Effects on Oral Tissues and Inflammatory Responses—Literature Review. Dent J (Basel). 2025;13(11). PMID 41294516
  9. A randomized controlled trial assessing denture adhesive efficacy on denture retention across 13 hours. J Prosthodont. 2024;33(S1). PMID 37805705
  10. Randomized Clinical Study Comparing Three Experimental Denture Adhesives and Fixodent versus No Adhesive. J Clin Dent. 2018;29(3):71-76. PMID 30942961
  11. Iinuma T, Arai Y, Abe Y, et al. Denture wearing during sleep doubles the risk of pneumonia in the very elderly. J Dent Res. 2015;94(3 Suppl):28S-36S. PMID 25294364
  12. Nations SP, Boyer PJ, Love LA, et al. Denture cream: an unusual source of excess zinc, leading to hypocupremia and neurologic disease. Neurology. 2008;71(9):639-643. PMID 18525032
  13. Zinc-Induced Hematologic Toxicities: A Systematic Review of Descriptive Studies. Biol Trace Elem Res. 2026;204(9):6628-6642. PMID 42087025
  14. Hyperzincemia from ingestion of denture adhesives. J Prosthet Dent. 2010;103(6):380-383. PMID 20493327
  15. Hypocupraemia-induced anaemia, sensory ataxia and cognitive impairment secondary to zinc-containing dental adhesive. BMJ Case Rep. 2021;14(7):e242178. PMID 34289999
  16. Acquired Hyperzincaemia Due to Zinc-Laden Denture Adhesives Leading to Hypocupraemia as a Cause of Neutropenia. Eur J Case Rep Intern Med. 2021;8(11):002946. PMID 34912740
  17. Impact of the Physiological Parameters of the Oral Cavity on the Mechanical Properties of Zinc-stabilized and Zinc-free Adhesive Creams: A Comparative In Vitro Study. J Adhes Dent. 2025;27:21-29. PMID 40063077
  18. Effects of Different Forms of Denture Adhesives on Biofilm Formation, Adhesive Strength and Hygiene of Complete Dentures. Int J Prosthodont. 2022;35(4):512-520. PMID 33750997
  19. Evaluation of the efficiency of denture cleaners for removing denture adhesives. Gerodontology. 2016;33(1):101-106. PMID 25643746
  20. Dynamic viscoelastic properties, water absorption, and solubility of home reliners. Dent Mater J. 2010;29(4):440-446. PMID 20733263
  21. Comparison of masticatory performance and oral hygiene status using cream-type denture adhesives and home liners: A cross-sectional study using propensity-score matching. J Oral Rehabil. 2024;51(11):2427-2434. PMID 39175130
  22. A web-based survey of denture adhesive use among denture wearers 40 years of age and older. J Oral Sci. 2020;63(1):98-100. PMID 32938837
  23. Factors Associated with Selection of Denture Adhesive Type: A Cross-Sectional Survey. J Clin Med. 2023;12(3):873. PMID 36769520
  24. Comparative Analysis of Adhesive Retention and Denture Weight in Different Residual Ridge Morphologies: A Cross-Over Randomized-Controlled Trial. Clin Exp Dent Res. 2025;11(2):e70113. PMID 40127129
  25. Multivariate analysis reveals oral health-related quality of life of complete denture wearers with denture adhesives: a multicenter randomized controlled trial. J Prosthodont Res. 2021;65(3):288-294. PMID 33116029
  26. Torres-Sánchez C, Montoya-Salazar V, Torres-Lagares D, Gutierrez-Pérez JL, Jimenez-Castellanos E. Comparison of masticatory efficacy among complete denture wearers with two adhesives and dentate individuals. J Prosthet Dent. 2017;117(5):614-620. PMID 27914670
  27. Influence of denture adhesives on occlusion and disocclusion times. J Prosthet Dent. 2016;116(5):770-777. PMID 26553256
  28. Inflammatory papillary hyperplasia: A systematic review. Med Oral Patol Oral Cir Bucal. 2017;22(1):e36-e42. PMID 27918740
  29. Prognosis of removable complete dentures considering the level of mandibular residual ridge resorption: a systematic review and meta-analysis. Clin Oral Investig. 2025;29(6):318. PMID 40394268
  30. Felton D, Cooper L, Duqum I, et al. Evidence-based guidelines for the care and maintenance of complete dentures: a publication of the American College of Prosthodontists. J Am Dent Assoc. 2011;142 Suppl 1:1S-20S. PMID 21282672
  31. The Assessment of Awareness and Attitudes About the Use of Denture Adhesives Amongst Dental Practitioners in Northern Maharashtra: A Delphi Technique. Cureus. 2024;16(1):e52509. PMID 38327924
  32. The effect of denture adhesive on the efficiency of complete denture in patients with different alveolar ridges. Dent Res J (Isfahan). 2018;15(4):270-274. PMID 30123304
  33. 醫療器材管理法 第 3 條（全國法規資料庫）
  34. 醫療器材管理法 第 25 條（全國法規資料庫）
  35. 醫療法 第 81 條（全國法規資料庫）
  36. 醫療法 第 87 條（全國法規資料庫）
  37. 醫療器材分類分級查詢資料庫（衛生福利部食品藥物管理署委託建置維護；連結列於食藥署「醫療器材」業務專區）
  38. 衛生福利部食品藥物管理署：西藥、醫療器材及化粧品許可證暨相關資料查詢——醫療器材許可證查詢
  39. 內部數據：`analysis/reports/km-dental-backlog.md` #31 附錄（詞×站×曝光逐筆可對帳）
  40. 編輯框架：本站分流問句、劑型對照與回診時機清單整理（無外部來源，標示為結構性整理）

內部引用鏈

  • 活動假牙本身的費用組成、襯底與修理的收費項目、以及適應期與維護：活動假牙要多少錢？先分清楚你要做的是哪一種、算的是哪一副（KM-DENTAL-13）——分工聲明：活動假牙的費用、襯底與維護屬該卡的 canonical 範圍，本卡不重寫，只在需要時引用。
  • 固定假牙的分流與報價單讀法：做一顆固定假牙要多少錢？（KM-DENTAL-03）
  • 缺牙不補會發生什麼、補牙的幾條路對照：臼齒拔掉可以不補嗎？會怎樣？（KM-DENTAL-34）
發布閘門提醒：本卡為 draft。四語（zh-Hans／en／ja）未產前不得進 km_entries；F33 為「入口已驗、個別品項未查」之查證管道，發布前如新增任何特定產品之許可證狀態，須先完成三件齊查證。

FAQ

假牙黏著劑可以連續黏多久？
**文獻量到的是「一次塗抹後十幾個小時內效果仍在」，不是「可以連續黏幾天」。** 一項 22 人的隨機交叉試驗在塗抹後 1 至 13 小時的每個時間點量到的咬合力都顯著高於未使用黏著劑 [F8]；另一項 48 人的試驗在 0.5 至 12 小時的每個時間點也是如此 [F9]。這些是量測期間的上限，不是使用時數的建議。個別產品的用法用量以其核准說明與牙醫師指示為準。至於「戴著睡覺」，一項極高齡社區長者的世代研究記錄，睡覺時戴假牙與肺炎發生風險相關（風險比 2.38，95% 信賴區間 1.25 至 4.56）[F10]，該研究為觀察性、族群特定，不能直接外推，但方向上不支持整天不取下的用法。
義歯安定剤は連続してどのくらい保てますか？ — **文献が測ったのは、1 回塗布後の十数時間であって、数日連続の固定ではありません。** 22 人試験では 1–13 時間、48 人試験では 0.5–12 時間の各時点で無使用より咬合力が高い結果でした [F8][F9]。測定期間の上限は使用時間の推奨ではありません。個別製品の用法・用量は承認説明書と歯科医師の指示に従ってください。睡眠中の装着は、平均 87.8 歳の観察研究で肺炎リスクとの関連（HR 2.38、95% 信頼区間 1.25–4.56）がありましたが、因果・一般化はできません [F10]。
How long can denture adhesive hold continuously? — The literature measures effect during a little over ten hours after one application, not continuous adhesion for several days. In a 22-person randomized crossover trial, bite force at every point from 1 to 13 hours after application was significantly higher than without adhesive [F8]; the same was true at every point from 0.5 to 12 hours in a 48-person trial [F9]. These are observation-period ceilings, not recommended hours of use. Use and dosage for individual products follow their approved instructions and the dentist’s directions. For sleeping with dentures, a cohort study of very old community-dwelling adults associated sleep-time wearing with pneumonia risk (hazard ratio 2.38, 95% confidence interval 1.25 to 4.56) [F10]. It is observational and population-specific and cannot be directly generalized, but its direction does not support never removing dentures all day.
膏狀、粉狀、墊片型，哪一種比較好？
**文獻的答案是「多數比較沒有差異」，而不是某一種比較好。** 納入 9 篇臨床研究的統合分析顯示，膏狀與粉狀在咀嚼表現上沒有差異、膏狀與貼片型在咬合力上沒有差異；只有在齒槽脊吸收明顯者，膏狀的咀嚼表現高於貼片型，而粉狀的咬合力高於貼片型——且所有結果的證據確定性都是極低 [F5]。實際適合哪一型，與齒槽脊條件、配戴時間等因素相關 [F22]，須由牙醫師依你的口腔狀況判斷。本卡不推薦任何品牌或商品。
クリーム、パウダー、クッション型のどれがよいですか？ — **多くの比較で差がない、というのが文献の答えです。** 顎堤吸収が著しい一部の人で差がありましたが、全結果の確実性は非常に低いです [F5]。顎堤状態や装着期間も関係するため [F22]、口腔内を診て歯科医師が判断します。ブランド・製品の推奨はしません。
Is cream, powder, or cushion form better? — The literature’s answer is that most comparisons found no difference, not that one form is better. A meta-analysis of 9 clinical studies found no cream–powder difference in masticatory performance and no cream–strip difference in occlusal force. Only in people with marked residual-ridge resorption did cream have higher masticatory performance than strips and powder higher occlusal force than strips—and certainty for every result was very low [F5]. Which form is appropriate is associated with factors such as residual-ridge condition and wearing duration [F22] and needs a dentist’s judgment from your oral condition. This guide recommends no brand or product.
我的假牙鬆了，多用一點黏著劑撐著可以嗎？
**不建議，而且這是本卡想講的重點。** 黏著劑毒性範疇回顧的結論句把「使用貼合良好的活動假牙、適當回診追蹤、正確的使用指示」列為優先 [F1]；一項測試家用襯墊材的研究結論寫明，這類材料從黏彈性與耐久性的角度看，不適合用於改善不密合的假牙 [F19]；台灣主管機關品項表對假牙黏著劑寫的用途，也只寫到「增加假牙之固持性和舒適性」[F31]。此外，持續使用不密合的假牙是黏膜病變的常見風險因子 [F2]，而「愈用愈多」正是鋅過量個案的典型情境 [F11][F12]。假牙鬆動請回診檢查，由牙醫師判斷要調整、襯底還是重做。
義歯がゆるいとき、安定剤を多く使ってしのげますか？ — **勧めません。** 適合のよい義歯、フォローアップ、正しい使用説明が優先です [F1]。家庭用リライナーは不適合義歯改善に適さないとされ [F19]、台湾の品目用途も維持と快適性の増加に限られます [F31]。不適合義歯の継続使用は粘膜病変のリスク因子で [F2]、使用量が増え続ける状況は亜鉛過量症例の典型です [F11][F12]。
My denture is loose. Can I use more adhesive to keep it going? — It is not recommended. The scoping review’s conclusion prioritizes well-adapted removable dentures, appropriate follow-up, and correct instructions [F1]. A study of home reliners concluded that, in terms of viscoelasticity and durability, they are not suitable for improving ill-fitting dentures [F19]. Taiwan’s authority item list also states the purpose only as increasing denture retention and comfort [F31]. Continued use of an ill-fitting denture is a common risk factor for mucosal lesions [F2], and “needing more and more” is the typical context of zinc-overuse cases [F11][F12]. If the denture is loose, return for examination so a dentist can decide on adjustment, relining, or remaking.

來源錨定

引用本文

km 編輯部・《假牙黏著劑怎麼選？可以黏多久？｜證據鏈》・IDAEO 知識庫・2026-08-13・https://km.idaeo.ai/reports/dental-denture-adhesive-evidence

相關文章

更新 2026-08-13T14:17:40.728Z · server-rendered · four-language · IDAEO 知識庫