Periodontal intrabony defects: how do Er,Cr:YSGG and minimally invasive surgery compare?｜證據鏈

This article discusses only data that explicitly identify Er,Cr:YSGG. The clinical evidence directly comparing an Er,Cr:YSGG protocol with the minimally invasive surgical technique (MIST) for periodontal intrabony defects comes from the same multicentre, randomised, masked trial (the abstracts state only "masked", without specifying who was masked): one report covers 6 months and the other covers 12 months. The two PMIDs complete the time series, but they still concern the same 53 adults and 79 defects and cannot be treated as two independent replications. At 12 months, 50 participants had completed follow-up. Standardised imaging estimated bone fill at 1.14 ± 1.73 mm for MIST and 1.12 ± 1.52 mm for Er,Cr:YSGG. The study tested non-inferiority using a prespecified margin; it did not prove that the treatments were completely equivalent, nor did it prove that Er,Cr:YSGG was superior to MIST. Before choosing, it remains necessary to confirm the defect morphology, the response to first-stage periodontal debridement, the patient's cleaning ability and whether the operator can reproduce the study protocol.